Johns Island is located to the west of James Island and to the east of Wadmalaw Island and inshore of Seabrook and Kiawah Islands which are to known for their large homes, famous golf courses and home to The Sanctuary Resort. It is separated from the mainland by the tidal Stono River, which forms part of the Intracoastal Waterway. Roughly one-third of the island is within the city limits of Charleston, with the remaining part in Charleston County. The island is home to Angel Oak, a famous live oak tree estimated to be 400–500 years old and named for Justus Angel, nineteenth-century owner of the land on which it stands. It is also known for its farms, producing tomatoes and numerous other agricultural products.
The population of Johns Island is growing as it is close to the historic city of Charleston as well as beaches and shopping.
The island's proximity to downtown and its scenic property have made it an active location for development. Numerous high-density developments have been created in parts of the island zoned into the City.
Several movies have been filmed on the island, including The Notebook (2004).